Programme
7th International Conference on
Plasmodium vivax Research (ICPvR)
Paris, June 26-28, 2019
Auditorium of CIS
Tuesday, June 25, 2019

On Tuesday 25th June, there will be two side meetings ahead of the International Conference on P. vivax Research (ICPVR) at Institut Pasteur in Paris.
 
09:00 am - 12:00 pm

Data analytics and modelling for P. vivax

01:30 pm - 04:30 pm

The Potential Use of Serology in Malaria Elimination

The meetings will be held on campus at Institut Pasteur. Please contact michael.white@pasteur.fr if you would like to attend.

Wednesday, June 26, 2019
Plenary Session
11:00 am-12:30 pm
Chair: Chetan Chitnis, (Chair), Institut Pasteur, France
1
11:00 am

History and current status of Plasmodium vivax malaria

G. Snounou
CEA Université Paris Sud 11, Inserm U1184, CNRS, Fontenay-Aux-Roses, France 
2
11:45 am

Biology of Plasmodium vivax

W. Tham
Walter and Eliza Hall Institute, Melbourne, Australia 
Lunch
12:30 pm-02:00 pm
Epidemiology of Plasmodium vivax malaria (burden, distribution and tools for detection)
02:00 pm-04:05 pm
Chairs: Ivo Mueller, (Vice Chair), Institut Pasteur, France - Dionicia Gamboa, Universidad Peruana Cayetano Heredia, Peru
3
02:00 pm

How can the epidemiology of Plasmodium vivax inform the safe and effective radical cure of malaria ?

R. Price
Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine Research Building, University of Oxford Old Road Campus, Oxford, United Kingdom 
4
02:30 pm

Plasmodium vivax malaria in the Pacific and S America

L. Robinson*1, D. Gamboa2
1Walter and Eliza Hall Institute, Melbourne, Australia 2Universidad Peruana Cayetano Heredia, Lima, Peru 
5
03:00 pm

Mapping the global burden of Plasmodium vivax malaria

K. Battle
University of Oxford, United Kingdom 
6
03:15 pm

Estimating the probable cause of recurrence in Plasmodium vivax malaria: relapse, reinfection or recrudescence?

A. Taylor*1, J. Watson2-3, C. Chu4-3, F. Nosten2-3, O. Buckee1, M. Imwong2-5, N. White2-3
1Harvard T.H. Chan School of Public Health, Boston, United States 2Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand 3University of Oxford, Oxford, United Kingdom 4Shoklo Malaria Research Unit, Mae Sot, Thailand 5Mahidol University, Bangkok, Thailand 6Broad Institute of MIT and Harvard, Cambridge, United States 
7
03:30 pm

Basic features of managed Plasmodium vivax and Plasmodium falciparum infections

J. Henry, R.C. Reiner, D. Smith*
Institute for Health Metrics and Evaluation, University of Washington, Seattle, United States 
8
03:45 pm

Spatio-temporal analysis in a Plasmodium vivax population from Amazon Forest, Brazil

T. De Oliveira*1, A. Early2-3, T. Farell2-3, P. Rodrigues1, R. Kuzma3-2, M. Menezes1, J. Alvez1, D. Neafsey2-3, M. Ferreira1
1Institute of Biomedical Science, University of Sao Paulo, Sao Paulo, Brazil 2Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Boston, United States 3Departament of Immunology and Infectious Diseases, Harvard T. Chan School of Public Health, Boton, United States 
9
03:50 pm

Prevalence, risk heterogeneity, and spatial dependence of Plasmodium vivax and Plasmodium falciparum infections: Two cross-sectional surveys in a remote area in Cambodia offer basis to tailor malaria elimination strategies

M. Sandfort*1-2, A. Vantaux3, S. Kim3, T. Obadia1-4, S. Gardais1, N. Khim3, M. White1-5-6, L. Robinson5-7-8, B. Witkowski3, I. Mueller1-5-7
1Malaria: Parasites & Hosts, Institut Pasteur, Paris, France 2Collège doctoral, Sorbonne Université, Paris, France 3Institut Pasteur du Cambodge, Phnom Penh, Cambodia 4Hub Bioinformatique et Biostatistique, Institut Pasteur, Paris, France 5Division of Population Health & Immunity, Walter and Eliza Hall Institute, Melbourne, Australia 6MRC Centre for Outbreak Analysis & Modelling, Imperial College, London, United Kingdom 7University of Melbourne, Parkville, Vic, Australia 8Burnet Institute, Melbourne, 3004, Vic, Australia 
10
03:55 pm

Natural Frequency, Timing and Multiplicity of Recurrences by Plasmodium vivax acquired in south Sumatra, Indonesia

I. Sutanto*1, L. Ekawati2, K. Chand2, T. Adelia2, B. Santoso3, H. Trijoko4, A. Karius4, I. Elyazar2, J.K. Baird2-5
1Department of Parasitology, Universitas Indonesia, Jakarta, Indonesia 2Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia 3Province Health Office, Lampung, Indonesia 4District Health Office, Pesawaran, Lampung, Indonesia 5Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom 
11
04:00 pm

Challenges in consolidating the evidence of Plasmodium vivax in Africa

K. Twohig*1, D. Pfeffer2-1, K. Battle1, R. Howes1
1Malaria Atlas Project, Oxford, United Kingdom 2Menzies School of Health Research and Charles Darwin University, Darwin, Australia 
Coffee Break
04:05 pm-04:35 pm
Plasmodium vivax gametocytes and transmission
04:35 pm-06:40 pm
Chairs: Catherine Lavazec, Institut Cochin, France - Wang Nguitragool, Faculty of Tropical Medicine, Mahidol University, Thailand
12
04:35 pm

Lessons learnt through ultra-sensitive detection of asexual and sexual parasites in population-based studies

I. Felger
Swiss Tropical and Public Health Institute, Basel, Switzerland 
13
05:05 pm

Plasmodium vivax in the bone marrow: basic biology and implications for interventions

M. Marti
University of Glasgow, United Kingdom 
14
05:35 pm

Novel insights to understand vivax malaria transmission in Cambodia: vector ecology and infectivity

A. Vantaux*1, J. Péneau1, S. Chy1, S. Kim1, D. Lek2, S. Siv2, K. Vernick3, I. Mueller4, B. Witkowski1
1Malaria Molecular Epidemiology Unit, Institut Pasteur, Phnom Penh, Cambodia 2National Center for Parasitology, Entomology and Malaria Control Program, Phnom Penh, Cambodia 3Genetics and Genomics of Insect Vectors Unit, Institut Pasteur, Paris, France 4Malaria: Parasites & Hosts Unit, Institut Pasteur, Paris, France 
15
05:50 pm

Investigation of two vaccine-delivery platforms to enhance immunogenicity and transmission-blocking activity of malaria vaccine candidate Pvs25

A. Marini*1, D. Nikolaeva2, Y. Li1, Y. Zhou1, K. Ellis1, W. Roobsoong2, S. Thongpoon2, J. Sattabongkot2, S. Biswas1
1Jenner Institute, University of Oxford, Oxford, United Kingdom 2Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand 
16
06:05 pm

A hidden biomass of non-phagocytosed asexual and sexual stages of Plasmodium vivax and Plasmodium falciparum in the human spleen

S. Kho*1, L. Leonardo2, B. Andries2, P. Shanti3, L. Qotrunnada4, B. Henry5, D. Hardy6, N. Margyaningsih4, D. Apriyanti4, A. Puspitasari4, P. Prayoga2, D. Lampah2, L. Triyanty4, Z. Korsten1, E. Kenangalem2-3, R. Price1-7, F. Chretien6, G. Jouvion6, J. Poespoprodjo2-8, R. Noviyanti4, T. Yeo1, T. Woodberry1, A. Ndour5, B. Russell9, G. Minigo1, N. Siregar4-10, P. Buffet5, N. Anstey1
1Global and Tropical Health, Menzies School of Health Research, Tiwi, Australia 2Timika Malaria Research Program, Papuan Health and Community Development Foundation, Timika, Indonesia 3Rumah Sakit Umum Daerah Kabupaten Mimika, Timika, Indonesia 4Eijkman Institute for Molecular Biology, Jakarta, Indonesia 5Institut National de la Transfusion Sanguine and Laboratory of Excellence GR-Ex, Paris, France 6Institut Pasteur, Paris, France 7Center for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom 8Department of Pediatrics, Gadjah Mada University, Yogyakarta, Indonesia 9Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand 10Department of Anatomical Pathology, Universitas Indonesia and Rumah Sakit Cipto Mangunkusumo, Jakarta, Indonesia 
17
06:20 pm

The role of the JNK and Toll pathways in the innate immune response of Anopheles aquasalis in Plasmodium vivax infection

A. Duarte*1-2, A. Orfano3, B. Costa3, R. Alencar1-2, M. Barbosa Guerra1-2, N. Secundino3-1, M. Lacerda2-4, W. Monteiro1-2, P. Pimenta3-1
1Post Graduate Program in Tropical Medicine (PPGMT), State University of Amazonas-UEA, Manaus, Brazil 2Instituto de Pesquisas Clínicas Carlos Borborema, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil 3Laboratory of Medical Entomology, Instituto René Rachou-FIOCRUZ-MG, Belo Horizonte, Brazil 4Instituto Leônidas & Maria Deane, FIOCRUZ-AM, Manaus, Brazil 
18
06:25 pm

Contribution of asymptomatic Plasmodium infections to the transmission of malaria in Kayin State, Myanmar

V. Chaumeau*1-2, M. Imwong3, L. Kajeechiwa1, J. Landier1, A. Dondorp2-3, N. White2-3, F. Nosten1-2
1Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae sot, Thailand 2Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom 3Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand 
19
06:30 pm

Serological analysis reveals heterogeneity and predicts hotspot of Plasmodium vivax transmission in a pre-elimination setting, Indonesia

H. Surendra*1-2, S. Supargiyono3-2, R. Ahmad4-2, R. Kusumasari3-2, T. Rahayujati5, S. Damayanti5, J. Cook6, C. Drakeley1
1Department of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, United Kingdom 2Centre for Tropical Medicine, Faculty of Medicine-Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia 3Department of Parasitology, Faculty of Medicine-Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia 4Department of Biostatistics, Epidemiology and Population Health, Faculty of Medicine-Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia 5District Health Office of Kulon Progo, Yogyakarta, Indonesia 6MRC Tropical Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom 
20
06:35 pm

Resurgence risk for malaria: characterization of a recent outbreak of Plasmodium vivax in a border area, French Guiana - Brazil, 2017

É. Mosnier*1-2, I. Dusfour3, G. Lacour3, J. Restrepo4, A. Guidez3, A. Sanna5, M. Gaillet6, M. Nacher7, V. Ardillon8, M. Douine7-2, Y. Lazrek9, F. Djossou1, M. Demar10, L. Musset9, E. Roux11
1Unité de Maladies Infectieuses et Tropicales, Centre Hospitalier Andrée Rosemon, Cayenne, France 2Equipe EA3593, Ecosystèmes amazoniens et Pathologie Tropicale, Université de la Guyane, Cayenne, Cayenne, France 3Unité Contrôle et Adaptation des Vecteurs, Institut Pasteur de la Guyane, Cayenne, France 4Service Entomologie, Direction Démoustication & Actions Sanitaires, Collectivité Térritoriale de la Guyane, Cayenne, France 5Agence Régionale de la Santé de la Guyane, Cayenne, France 6Pôle des Centres Délocalisés de Prévention et de Soins, Centre hospitalier Andrée Rosemon, Cayenne, France 7Centre d’Investigation Clinique Epidémiologie Clinique Antilles Guyane, Centre Hospitalier Andrée Rosemon, Cayenne, France 8CIRE Guyane, Cayenne, France 9Laboratoire de Parasitologie, Institut Pasteur de la Guyane, Cayenne, France 10Laboratoire de Parasitologie, Centre Hospitalier Andrée Rosemon, Cayenne, France 11ESPACE-DEV, IRD, Univ. de Montpellier, Univ. de La Réunion, Univ. de la Guyane, Univ. des Antilles, Montpellier, France ; LIS, ICICT, Fiocruz, Rio De Janeiro, Brazil 12Unité des Maladies Infectieuses et Tropicales, Centre Hospitalier de Cayenne et Université de la Guyane, Cayenne, France 
Welcome Reception and Poster Session 1
06:40 pm-09:00 pm
Thursday, June 27, 2019
Plasmodium vivax sporozoites and liver stages (hypnozoites, invasion, vaccines, immunity)
09:30 am-12:15 pm
Chairs: Dominique Mazier, Sorbonne Université, France - Erika Flannery, Novartis Institute of Tropical Diseases, United States
21
09:30 am

Analysis of Plasmodium-conserved essential genes in activation and infectivity of Plasmodium vivax sporozoites

J.H. Adams*, J. Oberstaller, A. Roth, J. Nicholas, S.R. Adapa, M. Zhang, X. Liao, S.J. Barnes, C. Herman, N.D. Salinas, N. Tolia, S. Davidson, R.H.Y. Jiang
Center for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, United States 
22
10:00 am

Plasmodium vivax liver stage biology and drug development

E. Flannery
Novartis Institute of Tropical Diseases, Oakland, United States 
23
10:30 am

Combination of Plasmodium vivax antigens to enhance pre-erythrocytic vaccine efficacy

A. Sandoval
Nuffield Department of Medicine, Jenner Institute, University of Oxford, Oxford, United Kingdom 
0
10:45 am

Coffee break


24
11:25 am

Unveiling the liver-stage transcriptome of vivax malaria parasites

L. Mancio Silva*1, N. Gural1, A. Miller1, V. Butty1, S. Levine1, S. March1, J. Sattabongkot2, S. Bhatia1
1Massachusetts Institute of Technology, Cambridge, United States 2Mahidol University, Bangkok, Thailand 
25
11:40 am

The metrics and critical factors behind operating a globally collaborative, medium throughput drug screen to find hypnozonticidal compounds

S. Maher*1, A. Vantaux2, J. Péneau2, C. Cooper1, M. Rouillier3, B. Campo3, M. Galinski4, C. Joyner4, B. Witkowski2, D. Kyle1
1Center for Tropical and Emerging Global Disease, University of Georgia, Athens, United States 2Malaria Molecular Epidemiology Unit, Institute Pasteur of Cambodia, Phnom Penh, Cambodia 3Medicines for Malaria Venture, Geneva, Switzerland 4Yerkes National Primate Research Center, Emory University, Atlanta, United States 
26
11:55 am

Use of an in vitro Plasmodium cynomolgi liver model for rapid discovery of next-generation drugs targeting hypnozoites

A. Roth*1, S. Aylor1, R. Ubalee2, G. Reichard1, S. Leed1, N. Roncal1, P. Lee1, B. Vesely1, S. Davidson2, N. Waters1, M. Kreishman-Deitrick1, B. Pybus1
1Experimental Therapeutics, Walter Reed Army Institute of Research, Silver Spring, United States 2Department of Entomology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand 
27
12:00 pm

Evaluation of humoral response of individuals naturally exposed to malaria against synthetic and recombinant antigens representing Plasmodium vivax TRAP protein

A. Matos*1, R. Nunes Rodrigues Da Silva2, I. Ferreira Soares1, B. De Oliveira Baptista3, L. Bitencourt Chaves1, P. Renato Rivas Totino3, L. Rose Pratt Riccio3, R. Medeiros De Souza4, C. Tadeu Daniel-Ribeiro3, C. Lopez Camacho5, A. Reyes-Sandoval4, J. Da Costa Lima Junior1
1Laboratório de Imunoparasitologia, Fundação Instituto Oswaldo Cruz - FIOCRUZ, Rio de Janeiro, Brazil 2Laboratory of Technology in Monoclonal Antibody, Bio-Manguinhos/FIOCRUZ, Rio De Janeiro, Brazil 3Laboratório de Pesquisas em Malária, Fundação Instituto Oswaldo Cruz, Rio De Janeiro, Brazil 4Universidade Federal do Acre - UFAC, Acre, Brazil 5The Jenner Institute, Oxford University, Oxford, United Kingdom 
28
12:05 pm

Plasmodium vivax sporozoites production in two South American Anophelines

R. Santana*1, C. Rios-Velasquez2, P. Fillemon Paolluci Pimenta3, W. Monteiro1, M. Rouillier4, B. Campo4, S. Costa Pinto Lopes2-1, M. Lacerda2-1
1Instituto de Pesquisa Clinica Carlos Borborema, Tropical Medicine Foundation Dr Heitor Vieira Dourado, Manaus, Brazil 2Instituto Leônidas & Maria Deane - Fiocruz Amazônia, Manaus, Brazil 3Instituto René Rachou – Fiocruz Minas, Belo Horizonte, Brazil 4Medicines for Malaria Venture - MMV, Geneva, Switzerland 
29
12:10 pm

Blood transfusion as a possible initiator of Plasmodium vivax relapse through increased heme metabolism leading to hepatocyte apoptosis

G. Shanks*1-2, M. Waller2
1Director, Australian Defence Force Malaria and Infectious Disease Institute, Enoggera, Australia 2School of Public Health, University of Queensland, Brisbane, Australia 
Lunch & Poster Session 2
12:15 pm-02:00 pm
Ex vivo and in vivo models to study Plasmodium vivax
02:00 pm-04:05 pm
Chairs: Georges Snounou, CEA-Université Paris Sud 11, INSERM U1184, CNRS, France - Mary Galinski, Emory University, United States
30
02:00 pm

Medium throughput radical cure drug discovery: Progress and insights

S. Maher1, A. Vantaux2, J. Peneau2, C. Cooper1, M. Rouillier3, V. Chaumeau4-5, F. Nosten4-5, M. Bakowski6, C. Mcnamara6, B. Campo3, B. Witowski2, D. Kyle*1
1University of Georgia, Athens, United States 2Pasteur Institute of Cambodia, Phnom Penh, Cambodia 3Medicines for Malaria Venture, Geneva, Switzerland 4Shoklo Malaria Research Unit, Mahidol Oxford Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand 5Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom 6Calibr at Scripps Research Institute, La Jolla, Ca, United States 
31
02:30 pm

Advances in the Plasmodium cynomolgi blood stage model for investigating vaccines and drugs against vivax malaria

B. Russell
University of Otago, New Zealand 
32
03:00 pm

Relapse infection biology insights using the Plasmodium cynomolgi rhesus macaque model

C. Joyner
Emory University, Atlanta, United States 
33
03:15 pm

Genome editing in Plasmodium knowlesi: A flexible and efficient model system to study blood stage Plasmodium vivax vaccine candidates and invasion biology

F. Mohring1, M. Hart1, T. Rawlinson2, R. Henrici1, J. Charleston1, E. Diez Benavente1, A. Patel1, J. Hall3, N. Almond3, S. Campino1, T. Clark1, C. Sutherland1, D. Baker1, S. Draper2, R. Moon*1
1Faculty of Infectious and Tropical Disease, London School of Hygiene and Tropical Medicine, London, United Kingdom 2The Jenner Institute, University of Oxford, Oxford, United Kingdom 3Division of Infectious Disease Diagnostics, National Institute of Biological Standards and Controls, Potters Bar, United Kingdom 
34
03:30 pm

A Plasmodium cynomolgi dual fluorescent reporter line to capture the dynamics of liver stage development and hypnozoite activation

A. Voorberg-van der Wel*, A. Zeeman, I. Nieuwenhuis, N. Van Der Werff, L. Vermaat, O. Klop, C. Kocken
Parasitology, BPRC, Rijswijk, The Netherlands 
35
03:45 pm

Continuous culture of Plasmodium cynomolgi aeexual blood stages as a model for vivax malaria

C. Cooper1, C. Joyner2, A. Elliot1, S. Maher1, M. Galinski2, D. Kyle*1
1University of Georgia, Athens, United States 2Emory University, Atlanta, Ga, United States 
36
03:50 pm

Single-cell mass cytometry during controlled human Plasmodium vivax infection reveals highly individual signatures of T cell responses

F. Bach*1, S. Silk2, Y. Themistocleous2-3, G. Napolitani4, M. Mazurcyk4, A. Minassian2-3, S. Draper2, P. Spence1
1University of Edinburgh, Edinburgh, United Kingdom 2Jenner Institute, University of Oxford, Oxford, United Kingdom 3Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Oxford, United Kingdom 4Weatherall Institute for Molecular Medicine, University of Oxford, Oxford, United Kingdom 
37
03:55 pm

Plasmodium vivax and rosetting: what can transcriptomics tell us?

C. Bourgard1, S. Lopes2-3, M. Lacerda2-3, F. Costa1, L. Albrecht*4-1
1Laboratory of Tropical Diseases – Prof. Dr. Luiz Jacintho da Silva, University of Campinas – UNICAMP, Campinas, Brazil 2Instituto Leônidas e Maria Deane, FIOCRUZ, Manaus, Brazil 3Gerência de Malária, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado – FMT-HVD, Manaus, Brazil 4Apicomplexan Research Laboratory, Instituto Carlos Chagas, FIOCRUZ, Curitiba, Brazil 
38
04:00 pm

Elucidating the intraerythrocytic Plasmodium vivax niche among the heterogeneous reticulocyte population

G. Rangel*1, U. Kanjee1, M. Clark1, K. Shaw-Saliba1, L. Nobre2, F. Raso1, J. Goldberg1, S. Gygi3, C. Brugnara4, M. Ferreira5, M. Weekes2, M. Duraisingh1
1Immunology and Infectious Diseases, Harvard T.H Chan School of Public Health, Boston, United States 2Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom 3Department of Cell Biology, Harvard Medical School, Boston, United States 4Department of Laboratory Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, United States 5Institute of Biomedical Sciences, Department of Parasitology, University of São Paulo, São Paulo, Brazil 
Coffee Break
04:05 pm-04:30 pm
Plasmodium vivax blood stages (invasion, immunity, pathogenesis and vaccines)
04:30 pm-06:35 pm
Chairs: Louis Miller, NIAID, United States - Hernando A Del Portillo, Barcelona Institute fro Global Health - ISGlobal, Spain
39
04:30 pm

Plasmodium vivax in Duffy negative individuals

P. Zimmermann
Case Western Reserve University, Cleveland, United States 
40
05:00 pm

Demonstration of the first controlled human malaria infection model in Europe for Plasmodium vivax vaccine efficacy testing

A. Minassian
Jenner Institute, University of Oxford, United Kingdom 
41
05:30 pm

Plasmodium vivax in African apes

V. Rougeron
Laboratoire MIVEGEC, CNRS, Montpellier, France 
42
05:45 pm

Molecular basis for inhibition of Plasmodium vivax reticulocyte invasion by a vaccine-induced broadly neutralising human monoclonal antibody

T. Rawlinson*1, N. Barber2, F. Mohring3, J. Cho1, V. Kosaisavee4, F. Nosten5-6, L. Renia7, A. Minassian1, R. Payne1, J. Marshall1, J. Jin1, D. Quinkert1, S. Silk1, S. Elias1, G. Labbe1, S. Gerard2, D. Alanine1, B. Russell8, R. Moon3, M. Higgins2, S. Draper1
1The Jenner Institute, University of Oxford, Oxford, United Kingdom 2Department of Biochemistry, University of Oxford, Oxford, United Kingdom 3Department of Immunology and Infection, London School of Hygiene and Tropical Medicine, London, United Kingdom 4Faculty of Public Health, Mahidol University, Bangkok, Thailand 5Shoklo Malaria Research Unit, Mae Sot, Thailand 6Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom 7Singapore Immunology Network, Singapore, Singapore 8Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand 
106
06:00 pm

Functional analysis reveals essential host factors for Plasmodium vivax invasion

U. Kanjee*1, R. Dash2, A. Mascarenhas2, L. Pereira2, A. Meyers1, E. Shabani1, E. Scully1, M. Clark1, G. Rangel1, C. Grüring1, L. Chery3, M. Ferreira4, P. Rathod3, M. Duraisingh1
1Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States 2Malaria Elimination in South Asia, International Centers of Excellence for Malaria Research, Goa Medical College Hospital, Bambolim, Goa, India 3Department of Chemistry, University of Washington, Seattle, Washington, United States 4Department of Parasitology, Institute for Biomedical Sciences, University of São Paolo, São Paolo, Brazil 
44
06:15 pm

Host immune escape of Plasmodium vivax through PvDBP gene amplification

C. Roesch*1, J. Popovici1, L. Carias2, N. Khim1, A. Vantaux1, C. Chitnis3, I. Mueller3-4, C. King2, B. Witkowski1
1Malaria Molecular Epidemiology Unit, Institut Pasteur du Cambodge (Phnom Penh), Phnom Penh, Cambodia 2Case Western Reserve University School of Medicine, Cleveland, United States 3Institut Pasteur, Paris, France 4WEHI, Melbourne, Australia 
45
06:20 pm

Plasma-derived extracellular vesicles from Plasmodium vivax patients act as inter-cellular communicators facilitating adherence of infected reticulocytes to the human spleen 

H. Toda1, R. Wanlapa2, M. Díaz-Varela1, B. Baro3-1, M.V.G. Lacerda3-4, P. Armengol5, H. Peinado6, J. Prachumsri2, C. Fernandez-Becerra1-5, H. Del Portillo*1-7
1PVREX group (https://pvrex.com), Barcelona Institute for Global Health - ISGlobal, Barcelona, Spain 2Mahidol Vivax Research Unit, Fac. of Tropical Medicine, Mahidol University, Bangkok, Thailand 3Malaria, Fundaçao de Medicina Tropical Dr. Heitor Vieira Dourado (FMT-HVD), Manaus, Brazil 4Instituto Leônidas & Maria Deane (ILMD), Fiocruz, Manaus, Brazil 5Institut Germans Trias i Pujol IGTP, Badalona, Spain 6Microenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid, Spain 7Institució Catalana de Recerca i Estudis Avançats (ICREA, Barcelona, Spain 
46
06:25 pm

The greater osmotic stability of reticulocytes is lost upon Plasmodium vivax infection

M. Clark*1, G. Rangel1, C. Brugnara2, M. Ferreira3, M. Duraisingh1
1Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, United States 2Department of Laboratory Medicine, Boston Children’s Hospital and Harvard Medical School, Boston, United States 3Institute Of Biomedical Sciences, Department Of Parasitology, University of São Paulo, São Paulo, Brazil 
47
06:30 pm

Identifying targets of functional antibody responses against Plasmodium vivax malaria

H. Opi*1, R. Longley2, L. Reiling1, D. Drew1, G. Feng1, M. Harbers3, T. Tsuboi4, I. Mueller2-5, J. Beeson1
1Life Sciences, Burnet Institute for Medical Research and Public Health, Melbourne, Australia 2Population Health and Immunity, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia 3CellFree Sciences Co., Ltd, Yokohama, Japan 4Division of Malaria Research, Proteo-Science Center, Ehime University, Matsuyama, Japan 5Institut Pasteur, Paris, France 
Conference dinner ''Musée d'Orsay''
07:00 pm-23:00
0
07:00 pm

Visit of the museum


0
08:45 pm

Dinner in the restaurant - 1st floor


Friday, June 28, 2019
Drugs for Plasmodium vivax, drug resistance, G6PD deficiency and treatment
09:30 am-12:15 pm
Chairs: Brice Campo, Medicines for Malaria Venture, Switzerland - G. Dennis Shanks, Australian Defence Force Malaria and Infectious Disease Institute, Australia
48
09:30 am

Efficacy and toxicity of 8-aminoquinolines for therapy of latent malaria

J. Baird
Eijkman Oxford Clinical Research Unit, Eijkman Institute of Molecular Biology, Jakarta, Indonesia Centre for Tropical Medicine and Public Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom 
49
10:00 am

Use of Tafanoquine for radical cure and elimination

M. Lacerda
FIOCRUZ, Manaus, Brazil 
50
10:30 am

Clinical spectrum of primaquine-induced hemolysis in G6PD deficiency: A 9-year hospitalization-based study from the Brazilian Amazon

J. De Brito Sousa*1-2, T. Santos2, S. Avalos3, G. Fontecha3, G. Melo1-2, F. Val1, A. Siqueira4, G. Alecrim1, Q. Bassat5-6, M. Lacerda1-7, W. Monteiro1-2
1International Center for Clinical Research in Malaria, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, Manaus, Brazil 2Universidade do Estado do Amazonas, Manaus, Brazil 3Microbiology Research Institute, Universidad Nacional Autónoma de Honduras, Tegucigalpa, Honduras 4Fiocruz - Instituto Nacional de Infectologia Evandro Chagas, Rio De Janeiro, Brazil 5ISGlobal, Hospital Clínic - Universitat de Barcelona, Barcelona, Spain 6ICREA, Barcelona, Spain 7Fiocruz - Instituto Leônidas e Maria Deane, Manaus, Brazil 
0
10:45 am

Coffee break


51
11:25 am

Short course primaquine for the radical cure of Plasmodium vivax malaria: a randomized placebo-controlled multicenter trial 

K. Thriemer
Menzies School of Health Research, Casuarina, Australia 
52
11:40 am

A comparison of two artemisinin combination therapies (ACTs) in combination with primaquine for radical cure of Plasmodium vivax malaria in the Solomon Islands: the “Act-Radical” study

R. James*1, L. Wini2, A. Bobogare2, T. Obadia3, S. Charnaud1, S. Zaloumis4, J.K. Baird5, I. Mueller1-3, H. Karunajeewa1
1Population Health and Immunity, Mueller Lab, The Walter and Eliza Hall Institute of Medical Research, Parkville, Australia 2National Vector Borne Disease Control Division, Solomon Islands Ministry of Health and Medical Services, Honiara, Solomon Islands 3Inisitut Pasteur, Paris, France 4The University of Melbourne, Melbourne, Australia 5The Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia 
53
11:55 am

Haemolytic dynamics of weekly primaquine anti-relapse therapy in G6PD-deficient and -normal Cambodians with acute vivax malaria

B. Taylor*1, S. Kheng2, S. Muth2, K. Kosal3, K. Sothea3, P. Souy4, C. Vanna5, E. Christophel6, C. Char2, P. Ly2, V. Khieu2, A. Kerleguer7, A. Pantaleo8, M. Mukaka1, N. Topps9, S. Bjorge9, S. Kim7, P. Tor7, D. Menard7, J. Baird10
1MORU, Bangkok, Thailand 2National Center for National Centre for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia 3Pailin Referral hospital, Pailin, Cambodia 4Anlong Veng Referral hospital, Anlong Veng, Cambodia 5Pramoy health centre, Veal Veng, Cambodia 6WPRO, Manila, Philippines 7Institut Pasteur du Cambodge, Phnom Penh, Cambodia 8University of Sassari, Sardinia, Italy 9WHO, Phnom Penh, Cambodia 10Eijkman Oxford Clinical Research Unit, Jakarta, Indonesia 
54
12:00 pm

Clinical evaluation of Tafenoquine in a paediatric Plasmodium vivax population – clinical trial simulations leading to optimal study design 

N. Goyal1, H. Sharma2, D. Austin3, K. Mohamed4, M. Taylor5, J. Green2, A. Martin2, V. Rousell2, J. Breton2, S. Duparc6, L. Tan*2
1Clinical Pharmacology, GlaxoSmithKline, Upper Providence, United States 2Global Health Research and Development, GlaxoSmithKline, London, United Kingdom 3Clinical Pharmacology, GlaxoSmithKline, London, United Kingdom 4Clinical Statistics, GlaxoSmithKline, London, United Kingdom 5Drug Metabolism and Pharmacokinetics, GlaxoSmithKline, Ware, United Kingdom 6Medicines for Malaria Venture, Geneva, Switzerland 
55
12:05 pm

Susceptibility factors and pharmacogenetics of treatment of Plasmodium vivax symptomatic infections in Cameroon

G. Djeunang Dongho*1-2, M. L'episcopia3-2, G. Maria Paganotti4-5, M. Menegon3, G. Bouting Mayaka6, R. Efeutmecheh Sangong7, C. Severini3, M. Sanou Sobze8-7, G. Russo2
1Faculty of Science and Technology, Evangelical University of Cameroon, Bandjoun, Cameroon 2Department of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy 3Malaria research Unit, Istituto Superiore di Sanità, Rome, Italy 4UB-UP Joint molecular Laboratory, Botswana-University of Pennsylvania Partnership, Gaborone, Botswana 5Department of Biomedical Science, University of Botswana, Gaborone, Botswana 6Dschang District Hospital, Dschang, Cameroon 7Projet Intégré pour la promotion de l’Auto-Développement (PIPAD), Dschang, Cameroon 8Faculty of Medicine and Pharmaceutical Sciences, University of Dschang, Dschang, Cameroon 
56
12:10 pm

Mathematical modelling of the roll-out and potential impact of Tafenoquine on Plasmodium vivax in Brazil

N. Nekkab*1, R. Lana2, M. Lacerda3-4, A. Siqueira5, W. Monteiro3, D. Villela2, I. Mueller1-6, M. White1
1Malaria: parasites and hosts, Institut Pasteur, Paris, France 2Programa de Computação Científica, Fundação Oswaldo Cruz (Fiocruz), Rio De Janeiro, Brazil 3Diretoria de Ensino e Pesquisa, Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Manaus, Brazil 4Instituto Leônidas e Maria Deane, Fundação Oswaldo Cruz (Fiocruz Amazônia), Manaus, Brazil 5Instituto Nacional de Infectologia Evandro Chagas, Fundação Oswaldo Cruz (Fiocruz), Rio De Janeiro, Brazil 6Population Health & Immunity Division, Walter and Eliza Hall Institute of Medical Research, Parkville, Australia 
Lunch & Poster Session 3
12:15 pm-02:00 pm
Approaches to Plasmodium vivax elimination (Treatment, surveillance, elimination)
02:00 pm-04:10 pm
Chairs: Marcus Lacerda, FIOCRUZ-AM, Brazil - Jane Carlton, New York University, United States
57
02:00 pm

Approaches to achieve Plasmodium vivax elimination

P. Alonso
WHO, Geneva, Switzerland 
58
03:00 pm

Challenges in rapid elimination of Plasmodium vivax

F. Nosten
Shoklo Malaria Research Unit, Thailand 
59
03:15 pm

The roles of genetic and genomic epidemiology in Plasmodium vivax elimination

S. Auburn
1 Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia 2 Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine Research Building, University of Oxford Old Road Campus, Oxford, United Kingdom 
60
03:30 pm

Population genomics of Plasmodium vivax from selective whole genome amplification to inform malaria elimination efforts in Panama

L. Buyon1, S. Bopp1, A.M. Santamaria2, M. Nunez2, I. Barahona3, J. Lasso3, S. Redmond4, J.E. Calzada2, S. Volkman1, M. Marti5-1, D. Neafsey1-4, N. Obaldia*2-1
1Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Ma, United States 2Department of Parasitology, Instituto Conmemorativo Gorgas de Estudios de la Salud, Panama, Panama 3Direccion General de Salud, Ministerio de Salud, Panama, Panama 4Broad Institute of MIT and Harvard, Cambridge, MA, United States 5Wellcome Trust Center for Molecular Parasitology, University of Glasgow, Glasgow, Scotland, United Kingdom 
61
03:45 pm

Understanding the response to serological markers of recent Plasmodium vivax infections

J. Rosado*1-2, M.T. White1, R. Longley3, A. Llanos-Cuentas4, J. Vinetz5-6, D. Gamboa5, I. Mueller1-3
1Malaria: Parasites et hotes, Institut Pasteur Paris, Paris, France 2Sorbonne Université, ED 393, F-75005, Paris, France 3Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia 4Instituto de Medicina Tropical “Alexander von Humboldt”, Universidad Peruana Cayetano Heredia, Lima, Peru 5Laboratorio ICEMR-Amazonia, Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru 6Division of Infectious Diseases, Department of Medicine, University of California San Diego School of Medicine, La Jolla, California, United States 
62
04:00 pm

Application of 23 novel serological exposure markers for identifying recent exposure to Plasmodium vivaxblood-stage parasites in an endemic-population of western Thailand

S. Chotirat*1, C. Kumpitak1, J. Hietanen2, K. Kiattibutr1, J. Brewster3, W. Nguitragool2-1, I. Mueller3-4, J. Sattabongkot1, R. Longley3-5
1Mahidol Vivax Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand 2Department of Molecular Tropical Medicine and Genetics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand 3The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia 4Department of Parasites & Insect Vectors, Institut Pasteur, Paris, France 5Department of Medical Biology, University of Melbourne, Melbourne, Victoria, Australia 
63
04:05 pm

Global economic costs due to Plasmodium vivax malaria treatment and the cost-benefit of radical cure

A. Devine*1-2, K. Battle3, R. Howes3-4, R. Price1-5, Y. Lubell5-6
1Menzies School of Health Research, Casuarina, Australia 2Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia 3Malaria Atlas Project, Big Data Institute, University of Oxford, Oxford, United Kingdom 4Center for Global Health and Diseases, Case Western Reserve University, Cleveland, United States 5Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom 6Mahidol-Oxford Tropical Medicine Research Unit, Bangkok, Thailand 
Coffee Break
04:10 pm-04:30 pm
Closing Plenary
04:30 pm-05:00 pm
0
04:30 pm

Roundtable Discussion: How can we achieve P. vivax elimination?

I. Mueller (vice Chair)
Institut Pasteur, Paris, France 

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